Malabaricone B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Malabaricone B 是一种香料衍生的酚类物质，它通过 p53 独立途径诱导肺癌细胞线粒体损伤。

Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.

Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM). The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 μM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3.Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans.

Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice.

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Others

Other Targets

Others

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63335-24-0

342.43

C21H26O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (292.03 mM)

Oc1ccc(CCCCCCCCC(c(c(O)ccc2)c2O)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years